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Probing protein communities with mass spectrometry
Budayeva and Kirkpatrick argue in their review Monitoring protein communities and their responses to therapeutics (Nature Reviews Drug Discovery, 2020) that mass spectrometry help us decipher complex relations between protein communities and understand how disease and drug influence them.
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A fresh look at tumour and immune-system dynamics in lung cancer
Nature published a collection of papers reporting the TRACERx study. It was set up in 2014 to study cancer dynamics and immune system changes during development of lung cancer.
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Discoveries Weekly No. 7 (May 25-31, 2020)
Here are the things I discovered this week that fascinates me.
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Nucleosome positioning and its prediction
Nucleosome positioning is an important factor determining whether a gene is actively transcribed. Together with transcription factor binding, it determines transcriptional behaviour.
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LOX mediates doxorubicin resistance in triple-negative breast cancer models
Saatci et al. report on Nature Communication that targeting lysyl oxidase (LOX) overcomes drug resistance in cellular and mouse models of triple-negative breast cancer. Here are my learning notes.