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Spotting problems that both matter and are computationally solvable
Derek Lowe’s blog post Calculating your way to antivirals is an interesting read about his reflection on computation (docking in particular) in drug discovery. Here are my learning notes and reflections.
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Discoveries Weekly No. 8 (June 1-7, 2020)
Here are some discoveries that fascinates me this week.
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RNA-guided endonuclease editing: history and testing in the clinic
Bruce Sullenger published a succinct review of the history and recent progress of RNA-guided endonuclease (RGEN) editing of RNA and DNA on Cell. Here are my learning notes.
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Probing protein communities with mass spectrometry
Budayeva and Kirkpatrick argue in their review Monitoring protein communities and their responses to therapeutics (Nature Reviews Drug Discovery, 2020) that mass spectrometry help us decipher complex relations between protein communities and understand how disease and drug influence them.
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A fresh look at tumour and immune-system dynamics in lung cancer
Nature published a collection of papers reporting the TRACERx study. It was set up in 2014 to study cancer dynamics and immune system changes during development of lung cancer.