David Discovers Drug Discovery
AboutResearchOutreach

Categories

medchem

edX Medicinal Chemistry - Chapter Six on Blood and Drug Transport

edX Medicinal Chemistry - Chapter Five on Receptors

edX Medicinal Chemistry - Chapter Four on enzymes

edX Medicinal Chemistry - Chapter Three on protein structures

edX Medicinal Chemistry - Chapter Two on the drug discovery process

edX Medicinal Chemistry - chapter one

machine-learning

Deep learning with graph networks

Machine Learning with CatBoost

Keras, a python deep learning library

Course on Natural Language Processing with Deep Learning - Stanford CS224n

A crash course to start state-of-the-art NLP in 2018

Ridge regression, LASSO, and elastic net explained

bioinformatics

Analysing single-cell T-cell receptor sequencing data with Scirpy

Nucleosome positioning and its prediction

Covariates and control variables explained

Filter BAM/SAM files by insert size

Pharmacogenomics of GPCR Drug Targets

programming

Read and look up words from Linux command line

Solution to the Git problem of loose object is corrupt

Continuous documentation, testing, and integration for R packages

Submitting Snakemake jobs to Slurm

Learning Logstash - Part I

Axis in Python and MARGIN in R explained

Linking native routines between R packages - a demo

Building R and/or R packages for Windows

Disable non-portable compiler flags with ~/.R/Makevars

Install R in Linux MINT 18

Develop R packages with Rcpp and RStudio

Notes on using sqlite3

career

RISE studentship to analyse vascular network images

Staying mentally healthy during the coronavirus pandemic

Talk at *Insight China*

Zürich Life Science Day 2018: presentation and impressions

DrugDiscovery

Public talk about target and modality selection in drug discovery

Introducing computational biology and multiscale modeling to pharmacists

A SPARK for therapeutic pathway hunting

Multispecific drugs reviewed

An application of machine learning for DNA-encoded library screening

Spotting problems that both matter and are computationally solvable

RNA-guided endonuclease editing: history and testing in the clinic

Probing protein communities with mass spectrometry

Welcome, Aviv Regev!

Bioinformatics approaches to understanding the MoA of a compound

Molecular Phenotyping in Drug Discovery

DiscoveryWeekly

Discoveries Weekly No. 16 (July 28-August 2, 2020): Zettelkasten

Discoveries Weekly No. 15 (July 20-July 26, 2020)

Discoveries Weekly No. 14 (July 13-July 19, 2020)

Discoveries Weekly No. 13 (July 6-July 12, 2020)

Discoveries Weekly No. 12 (June 29-July 5, 2020)

Discoveries Weekly No. 11 (June 22-28, 2020)

Discoveries Weekly No. 10 (June 15-21, 2020)

Discoveries Weekly No. 9 (June 8-14, 2020)

Discoveries Weekly No. 8 (June 1-7, 2020)

Discoveries Weekly No. 7 (May 25-31, 2020)

Discoveries Weekly No. 6 (May 18-24, 2020)

Discoveries Weekly No. 5 (May 11-17, 2020)

Discoveries Weekly No. 4 (May 4-8, 2020)

Discoveries Weekly No. 3 (April 25-May 1, 2020)

Discoveries Weekly No. 2 (April 20-27, 2020)

Discoveries Weekly No. 1 (April 13-20, 2020)

Notes

About time

Configuring the home wireless network

Mathematics

Learning from mathematical models of infectious-disease dynamics

Book

Nonviolent communication

Biology

Meta-analysis of single-cell RNA-sequencing studies for SARS-CoV-2

A fresh look at tumour and immune-system dynamics in lung cancer

LOX mediates doxorubicin resistance in triple-negative breast cancer models

Music

Chord sequence 1-6-2-5-1

Statistics

Three classical approaches to hypothesis testing

Degree of freedom in statistical testing

Genomics

Intrisincally disodered regions in transcription factors

MultiScaleModelling

Mathematical modelling and single-cell RNA sequencing for cancer immunotherapy

notes

Thoughts inspired by a recital of Igor Levit

AMIDD

Applied Mathematics and Informatics In Drug Discovery (2020)

Career

Postdoc position on intestinal human model systems and applications in modelling

Postdoc position on spatial transcriptomics and machine learning

Six-month internship in pharmacometrics for master/PhD students

Roche Predictive Modeling and Data Analytics Summer School 2022

Internship project on graph neural network and causal inference

Internship on immuno-safety

Internship on graph learning with patient-level data

Calling for Healthcare Xplorers

Two internship positions in my team

Neurobiology Ph.D. Program in Shenzhen

Bioinformatics Events

Roche PMDA Summer School 2024

Roche PMDA Summer School 2023

Genetoberfest, October 16-19 2023, Munich/Garching

children

Roche Zukunftstag 2023

biology

Micro RNA, Big Prize

  • Jitao David Zhang
  • mail@jdzhang.me

Subscribe GPG Key

Notes of a computational biologist working in drug discovery