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Mathematical modelling and single-cell RNA sequencing for cancer immunotherapy
Griffiths et al. reported on PNAS their effort of profiling peripheral immune cell abundance in time series following treatment of immunotherapy in a small clinical trial. I found the study interesting and here are my learning notes.
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Three classical approaches to hypothesis testing
Here I introduce three classical approaches to hypotheses testing in the frequentists’s approach of statistics: the likelihood-ratio test, the Lagrange multiplier test (or the score test), and the Wald test.
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Discoveries Weekly No. 10 (June 15-21, 2020)
Here are some discoveries that fascinate me this week.
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Intrisincally disodered regions in transcription factors
It is long known that transcription factors (TFs) which bind to common DNA motifs in vitro occupy distinct sets of promoters in vivo. The reason for that is not clear. A new study may provide some hints. Spoiler warning: it involves intrisincally disordered regions.
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An application of machine learning for DNA-encoded library screening
A post in the Google AI Blog features a paper by McCloskey et al (Journal of Medicinal Chemistry 2020), reporting an application of machine learning to DNA-Encoded Library (DEL) screening results. Here are my learning notes.